Tranexamic Acid Powder

Tranexamic Acid (TXA) is a synthetic lysine derivative originally developed as an antifibrinolytic agent in clinical medicine. In cosmetic formulation, it has emerged as one of the most versatile and well-tolerated brightening actives available — particularly valued for its multi-pathway approach to pigmentation control. Unlike single-mechanism inhibitors, TXA disrupts melanin synthesis through several complementary mechanisms: it blocks the interaction between keratinocytes and melanocytes by inhibiting plasminogen activator, reduces prostaglandin-mediated UV-induced pigmentation, and downregulates the expression of key melanogenic enzymes including tyrosinase. The result is a brightening active that addresses both existing discolouration and the inflammatory triggers that cause it.

What It Does in a Formula

• Multi-pathway pigmentation control — simultaneously targets plasminogen/plasmin signalling, prostaglandin pathways, and tyrosinase expression for broader efficacy than single-mechanism actives
• Effective against melasma — one of the few topical actives with robust clinical evidence for melasma reduction, including head-to-head studies against hydroquinone
• Reduces post-inflammatory hyperpigmentation (PIH) — particularly effective for PIH triggered by acne, eczema, or UV exposure
• Anti-inflammatory properties — helps calm the inflammatory cascade that drives reactive pigmentation, making it suitable for sensitive and reactive skin types
• Excellent tolerability — does not cause the irritation, rebound hyperpigmentation, or regulatory concerns associated with hydroquinone; safe for long-term use
• Synergistic pairing — works well alongside Niacinamide, Alpha Arbutin, Azelaic Acid, and Vitamin C for enhanced brightening protocols

Formulation Guidelines

• Use level: 2% – 5% (most clinical studies use 2–3%; up to 5% is used in leave-on treatments)
• Phase: Water phase — dissolve in the aqueous phase before emulsification; highly water soluble
• pH range: Stable across a broad pH range (3.0 – 7.0); most effective in slightly acidic to neutral formulations
• Compatibility: Compatible with most cosmetic actives and preservative systems; no known significant incompatibilities at standard use levels
• Formulator note: TXA is heat stable and can be added to the water phase at elevated temperatures without significant degradation, simplifying manufacturing
• Suitable formats: Serums, toners, moisturizers, eye creams, and targeted spot treatments

Technical Specifications

• INCI Name: Tranexamic Acid
• CAS Number: 1197-18-8
• Appearance: White crystalline powder
• Purity: ≥99%
• Solubility: Freely soluble in water; slightly soluble in ethanol; practically insoluble in oils
• pH (1% aqueous solution): 7.0 – 8.0
• Storage: Store in a cool, dry place away from direct light and moisture; keep container tightly sealed
• Shelf Life: 2 years from date of manufacture when stored properly